Whelan HT, Smits RL Jr, Buchman EV, Whelan NT, Turner SG, Margolis DA, Cevenini V, Stinson H, Ignatius R, Martin T, Cwiklinski J, Philippi AF, Graf WR, Hodgson B, Gould L, Kane M, Chen G, Caviness J.
Department of Neurology, Medical College of Wisconsin, Milwaukee 53226, USA.
OBJECTIVE: The purpose of this study was to assess the effects of hyperbaric oxygen (HBO) and near-infrared light therapy on wound healing. BACKGROUND DATA: Light-emitting diodes (LED), originally developed for NASA plant growth experiments in space show promise for delivering light deep into tissues of the body to promote wound healing and human tissue growth. In this paper, we review and present our new data of LED treatment on cells grown in culture, on ischemic and diabetic wounds in rat models, and on acute and chronic wounds in humans. MATERIALS AND METHODS: In vitro and in vivo (animal and human) studies utilized a variety of LED wavelength, power intensity, and energy density parameters to begin to identify conditions for each biological tissue that are optimal for biostimulation. Results: LED produced in vitro increases of cell growth of 140-200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155-171% of normal human epithelial cells. Wound size decreased up to 36% in conjunction with HBO in ischemic rat models. LED produced improvement of greater than 40% in musculoskeletal training injuries in Navy SEAL team members, and decreased wound healing time in crew members aboard a U.S. Naval submarine. LED produced a 47% reduction in pain of children suffering from oral mucositis. CONCLUSION: We believe that the use of NASA LED for light therapy alone, and in conjunction with hyperbaric oxygen, will greatly enhance the natural wound healing process, and more quickly return the patient to a preinjury/illness level of activity. This work is supported and managed through the NASA Marshall Space Flight Center-SBIR Program.
Publication Types:
Review
Review, Tutorial
PMID: 11776448 [PubMed - indexed for MEDLINE]
1: J Clin Laser Med Surg. 2001 Dec;19(6):305-14.
- Thermographic study of Low Level Laser Therapy for ACUTE-PHASE INJURY
- Low-level laser therapy is an important tool to treat disorders of the maxllofacial region (TMJ).
- General Motors Study Low Level Laser Therapy in the Treatment of CARPAL TUNNEL SYNDROME
- Laser therapy is effective for DEGENERATIVE OSTEOARTHRITIS
- Efficacy of low power laser therapy and exercise on pain and functions in CHRONIC LOW BACK PAIN.
- Efficacy of low power laser therapy in FIBROMYALGIA: a single-blind, placebo-controlled trial.
- Laser Therapy in the Treatment of DENTAL HYPERSENSITIVITY. A Histologic Study And Clinical Application.
- Low level laser therapy with trigger points technique: a clinical study of 243 patients. (HEADACHES & faacial pain, skeletomuscular ailments, myogenic NECK PAIN, SHOULDER AND ARM PAIN, epicondylitis humery, tensosynovitis, low back & radicular pain & archilles tendinitis)
- Efficacy of low level laser therapy in MYOFASCIAL PAIN SYNDROME: an algometric and thermographic evaluation.
- Low-level laser therapy in OSTEOARTICULAR DISEASES in geriatric patients.
- WOUND HEALING of animal and human body sport and traffic accident injuries using low-level laser therapy treatment: a randomized clinical study of seventy-four patients with control group.
- The interauricular laser therapy of RHEUMATOID ARTHRITIS.
- Laser therapy of RHEUMATOID ARTHRITIS
- The prevention of INFLAMMATORY COMPLICATIONS IN MANDIBULAR FRACTURES by using infrared laser and magnetic-laser radiation
- Laser therapy for FIBROMYOSITIC RHEUMATISMS
- The clinical efficacy of low-power laser therapy on pain and function in CERVICAL OSTEOARTHRITIS
- Effect of NASA light-emitting diode irradiation on WOUND HEALING
- CARPAL TUNNEL SYNDROME pain treated with low-level laser and microamperes transcutaneous electric nerve stimulation: A controlled study
- CARPAL TUNNEL SYNDROME: clinical outcome after low-level laser acupuncture, microamps transcutaneous electrical nerve stimulation, and other alternative therapies--an open protocol study
- PROMOTION OF ANGIOGENESIS by low energy laser irradiation.
- Effect of red and near-infrared laser light on ADENOSINE TRIPHOSPHATE (ATP) in the luciferine–luciferase reaction.
- Effect of a diode laser on WOUND HEALING by using diabetic and nondiabetic mice.
- Low Level Laser Therapy—a conservative approach to the BURN SCAR
- Effects of low-intensity laser therapy on the ORTHODONTIC movement velocity of human teeth: a preliminary study.
- Diode Laser In CERVICAL MYOFASCIAL Pain: A Double-Blind Study Versus Placebo
- Infared Diode Laser In Low Reactive-Level Laser Therapy (LLLT) For KNEE OSTEOARTHROSIS
- Successful Management Of Female Office Workers With "REPETITIVE STRESS INJURY" Or "CARPAL TUNNEL SYNDROME" By A New Treatment Modality Application Of Low Level Laser
- The use of infrared laser therapy (LLLT) in the treatment of VENOUS ULCERATION
- Light therapy (LLLT) alters gene expression after ACUTE SPINAL CORD INJURY
- Low level laser therapy (LLLT) in ambulatory patients with VENOUS STASIS ULCERS
- The use of low energy photon therapy (LEPT) in VENOUS LEG ULCERS: a double blind, placebocontrolled study
- The effect of infr-ared laser irradiation (LLLT) on the duration and severity of POSTOPERATIVE PAIN: a double blind trial
- Effects of phototherapy (LLLT) on pressure ULCER HEALING in elderly patients after a falling trauma. A prospective, randomized, controlled study.
- The use of low intensity laser therapy (LLLT) for the TREATMENT OF OPEN WOUNDS in psychogeriatric patients: a pilot study.
- Can low reactive-level laser therapy (LLLT) be used in the treatment of NEUROGENIC FACIAL PAIN? A double-blind, placebo controlled investigation of patients with trigeminal neuralgia
- Clinical application of GaAlAs 830nm diode laser (LLLT) in treatment of RHEUMATOID ARTHRITIS